Work Package: WP4
Deliverable: Deliverable 10.2: “Ordering effects of random fluctuations at the mesoscopic level”
Deliverable due date: month 36
This document reports on the progress of work on Deliverable 10.2.
In the NETT 289146 Grant Annex, we stated in the context of Deliverable 10.1 and 10.2: “P10 addresses modelling at a mesoscopic level of neuronal activity to complement experimental data obtained using neural mass models; it will study the effects of noise, and relate the results obtained with potential coordination malfunctions leading to aberrant synchronized behaviour and subsequently to neurological disorders.”
In Deliverable 10.2 we elaborated on relating our previous results (see Deliverable 10.1 report) to neurological disorders, namely to epilepsy. Our preliminary conclusions were presented on a poster session on the annual meeting of Organization for Computational Neuroscience in Prague, 2015. Abstract of this work can be found here: http://www.biomedcentral.com/1471-2202/16/S1/P75. Primarily it describes our results related to resonance effects, but it is also concerned with epileptic activity. This part of work is mentioned in the following part of the abstract: “We show that the correlation time of the noise is one of the crucial factors that modulate the preference of dynamical regimes for a single compartment, and thus determine the model's activity.” Distinct “dynamical regimes” refer here to either healthy and epileptic brain dynamics.
The ESR was invited to give a talk on these results on Donders Discussion conference in Nijmegen in Novemeber 2015. The abstract of his talk can be found here: http://www.ru.nl/dondersdiscussions/donders-discussions-0/oral-sessions/session-3-frontiers/maciej-jedynak/
It says explicitly about the focus on epilepsy and synchrony of brain activity:
“We find that preference of the activity type depends in a non-monotonous way on the correlation time of the driving noise. We relate these results to brain stimulation protocols in the context of neuronal diseases. Furthermore, we show how interactions between neuronal assemblies in the presence of noise lead to synchronization effects observed in epileptic seizures.”
Currently the ESR and his supervisors, along with their collaborator Marc Goodfellow from the University of Exeter (the ESR established this collaboration during his secondment) are preparing for publication the manuscript describing aforementioned results. They estimate that the manuscript will be submitted in May 2016 and published in press in autumn 2016.
This work also covers milestone 21.
Contributors: Maciej Jedynak, Jordi Garcia-Ojalvo, Antonio J Pons (UPC)